The nurse instructs a patient who is taking fludrocortisone for adrenal hypofunction to report which symptom to the health care provider?

• A. Weight gain
• B. Weight loss
• C. Fever
• D. Cough and shortness of breath

Answer: (A)

Fludrocortisone acts as a mineralocorticoid, promoting sodium and water reabsorption and potassium excretion. When the dose is higher than needed, this mineralocorticoid effect can cause fluid retention, leading to weight gain, edema, and potential increases in blood pressure. Because weight gain reflects excess mineralocorticoid activity, it’s a key sign to report so the dose can be adjusted to avoid complications.

Fever or cough/shortness of breath point to infections or other conditions rather than a direct drug effect, and weight loss would suggest under-replacement with dehydration and electrolyte imbalance rather than over-replacement.