Which sign is most specific for an adrenal source of androgen excess in a female?

Study for the Disorders of the Adrenal Gland Test. Use flashcards and multiple-choice questions, each with hints and explanations. Prepare for your exam!

Multiple Choice

Which sign is most specific for an adrenal source of androgen excess in a female?

Explanation:
Virilization signals very high androgen exposure. Clitoromegaly is the most specific sign of this level of androgen effect, reflecting irreversible changes to the external genitalia from substantial androgen excess. That makes it a strong clue for an adrenal source (or an androgen-secreting tumor) of excess androgens. In contrast, hirsutism, oily skin, and acne can occur with milder androgen elevations and from a variety of conditions, so they are less specific indicators of an adrenal origin.

Virilization signals very high androgen exposure. Clitoromegaly is the most specific sign of this level of androgen effect, reflecting irreversible changes to the external genitalia from substantial androgen excess. That makes it a strong clue for an adrenal source (or an androgen-secreting tumor) of excess androgens. In contrast, hirsutism, oily skin, and acne can occur with milder androgen elevations and from a variety of conditions, so they are less specific indicators of an adrenal origin.

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